The Phagmodrupa dynasty or Pagmodru was a dynastic regime that held sway over Tibet or parts thereof from 1354 to the early 17th century.
It was established by Tai Situ Changchub Gyaltsen of the Lang family at the end of the Yuan dynasty.
The dynasty had a lasting importance on the history of Tibet; it created an autonomous kingdom after Mongol rule, revitalized the national culture, and brought about a new legislation that survived until the 1950s.
Nevertheless, the Phagmodrupa had a turbulent history due to internal family feuding and the strong localism among noble lineages and fiefs.
Its power receded after 1435 and was reduced to Ü in the 16th century due to the rise of the ministerial family of the Rinpungpa. It was defeated by the rival Tsangpa dynasty in 1613 and 1620, and was formally superseded by the Ganden Phodrang regime founded by the 5th Dalai Lama in 1642.
In that year, Güshi Khan of the Khoshut formally transferred the old possessions of Sakya, Rinpung and Phagmodrupa to the "Great Fifth".
The Tibetan kingdom was centered on the Tibetan Plateau, formed as a result of imperial expansion under the Yarlung dynasty heralded by its 33rd king, Songtsen Gampo, in the 7th century.
The empire further expanded under the 38th king, Trisong Detsen.
The 821–823 treaty concluded between the Tibetan Empire and the Tang dynasty delineated the former as being in possession of an area larger than the Tibetan Plateau, stretching east to Chang'an, west beyond .